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Pegaptanib sodium

Names

[ CAS No. ]:
222716-86-1

[ Name ]:
Pegaptanib sodium

Biological Activity

[Description]:

Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) [1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[In Vitro]

Pegaptanib also inhibits VEGF165-mediated phosphorylation of VEGFR2 and phospholipase Cγ and inhibited VEGF165-induced calcium mobilization in human umbilical vein endothelial cells[1].

[References]

[1]. Eugene W M Ng, et al. Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov. 2006 Feb;5(2):123-32.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds