RIP1 kinase inhibitor 8

Names

[ Name ]:
RIP1 kinase inhibitor 8

Biological Activity

[Description]:

RIP1 kinase inhibitor 8 (Compound 77) is a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor with an IC50 of 20 nM. RIP1 kinase inhibitor 8 prevents necrotic cell death. RIP1 kinase inhibitor 8 shows a favorable pharmacokinetic profile in multiple species[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> RIP kinase

Research Areas >> Inflammation/Immunology

[Target]

IC50: 20 nM (RIP1)[1]

[References]

[1]. Harris PA, et al. Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase. J Med Chem. 2019 May 23;62(10):5096-5110.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₉F₂N₅O₂

[ Molecular Weight ]:
375.37

Related Compounds

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