TSR-033

Names

[ Name ]:
TSR-033

Biological Activity

[Description]:

TSR-033 is a high affinity human IgG4 antibody targeting LAG-3 (lymphocyte activation gene-3), a co-receptor associated with impaired T cell function and often co-expressed with PD-1, that enhances T cell function and PD-1 blocking activity in vitro and in vivo. TSR-033 has anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

TSR-033 (0.01-1000 nmol/L, 48 h) 可以增加原代人类 CD4 T细胞和树突状细胞的 IL2 产生，并增强T细胞效应器功能[1]。

[In Vivo]

TSR-033 (i.p.,10 mg/kg, twice weekly, 40 days) 在 A549 HuNOG-EXL NSCLC 小鼠肿瘤模型中，对肿瘤生长有中等程度的抑制作用，单独治疗终止时TGI 为 23%，而与 TSR-042 联合治疗有累积效应，能更大程度地阻碍肿瘤生长，终止时 TGI 为 45%[1]。

[References]

[1]. Srimoyee Ghosh, et al. TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo. Mol Cancer Ther. 2019 Mar;18(3):632-641.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.