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methyl 6-hydroxyangolensate

Names

[ CAS No. ]:
22255-07-8

[ Name ]:
methyl 6-hydroxyangolensate

[Synonym ]:
7,12a-Methano-2H,4H-pyrano[4,3-b][1]benzoxocin-8-acetic acid, 4-(3-furanyl)undecahydro-α-hydroxy-4a,7a,9,9-tetramethyl-13-methylene-2,10-dioxo-, methyl ester, (αS,4S,4aS,7R,7aR,8R,11aS,12aS)-
Methyl (2S)-[(1S,3S,7R,8R,9R,12S,13S)-13-(3-furyl)-6,6,8,12-tetramethyl-17-methylene-5,15-dioxo-2,14-dioxatetracyclo[7.7.1.0.0]heptadec-7-yl](hydroxy)acetate

Biological Activity

[Description]:

6-Methylhydroxyyangolensate is a limonoid can be extracted from Khaya grandifoliola. 6-Methylhydroxyyangolensate has low antimalarial activity in vitro, with an IC50 of 21.59 μg/ml against P. falciparum (W2/Indochina clone)[1].

[Related Catalog]:

Research Areas >> Infection

[References]

[1]. Bickii J, et al. In vitro antimalarial activity of limonoids from Khaya grandifoliola C.D.C. (Meliaceae). J Ethnopharmacol. 2000 Jan;69(1):27-33.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
630.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H34O8

[ Molecular Weight ]:
486.55

[ Flash Point ]:
334.8±31.5 °C

[ Exact Mass ]:
486.225372

[ PSA ]:
112.27000

[ LogP ]:
2.23

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.571

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds