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Thalidomide-O-C8-Boc

Names

[ CAS No. ]:
2225148-52-5

[ Name ]:
Thalidomide-O-C8-Boc

Biological Activity

[Description]:

Thalidomide-O-C8-Boc is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-Boc can be connected to the ligand for protein by a linker to form PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon


[References]

[1]. Nathanael S. Gray, et al. Degraders of wee1 kinase. WO2020069105A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H34N2O7

[ Molecular Weight ]:
486.56

[ Storage condition ]:
-20°C

Related Compounds