Thalidomide-O-C8-COOH

Names

[ Name ]:
Thalidomide-O-C8-COOH

Biological Activity

[Description]:

Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

[Target]

Cereblon

[References]

[1]. Nathanael S. Gray, et al. Degraders of wee1 kinase. WO2020069105A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₆N₂O₇

[ Molecular Weight ]:
430.45

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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