Jaspamycin

Names

[ Name ]:
Jaspamycin

[Synonym ]:
6-Phenyl-5-cyan-uracil
5-Cyano-6-phenyl-2,4(1H,3H)-pyrimidinedione
5-Cyano-2,4-dioxo-6-phenyl-1,2,3,4-tetrahydro-pyrimidin
5-Cyano-6-phenyluracil
2,4-dioxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

Biological Activity

[Description]:

Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA

Signaling Pathways >> Stem Cell/Wnt >> PKA

[Target]

Trypanosoma brucei PKAR(199-499):6.5 nM (EC50)

Trypanosoma brucei PKA holoenzyme:8 nM (Kd)

[References]

[1]. Sabine Bachmaier, et al. Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 2019 Mar 29;10(1):1421.

Chemical & Physical Properties

[ Density]:
1.91g/cm3

[ Boiling Point ]:
724.3ºC at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₂N₄O₅

[ Molecular Weight ]:
292.25

[ Flash Point ]:
391.8ºC

[ Exact Mass ]:
292.08100

[ PSA ]:
144.39000

[ Vapour Pressure ]:
5.1E-22mmHg at 25°C

[ Index of Refraction ]:
1.827

Precursor & DownStream

Precursor

DownStream

Related Compounds

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