As-358

As-358 has inhibitory effects against Ebola virus and Marburg virus, with IC50s of 47.5 μM and 3.7 μM[1].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Filovirus

IC50: 47.5 μM (EBOV), 3.7 μM (MARV)[1]

As-358 (compound 3b) (0-500 μM; 10 days) exhibits inhibitory activities against EBOV and MARV[1]. As-358 (0-100 μM; 48 hours) can inhibit WT-EboV-GP and mutant D522A-EboV-GP, with IC50s of 1.7 and 2.2 μM, respectively[1]. Cell Proliferation Assay Cell Line: Vero (infected with EBOV and MARV)[1] Concentration: 0-500 μM Incubation Time: 10 days Result: Exhibited inhibitory activities against EBOV and MARV, with IC50s of 47.5 ± 8.2 μM and 3.7 ± 1.7 μM, SI values of 9 and 118, respectively.

[1]. Sokolova AS, Yarovaya OI, Zybkina AV, et al. Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process. Eur J Med Chem. 2020;207:112726.