ML211

Names

[ CAS No. ]:
2205032-89-7

[ Name ]:
ML211

[Synonym ]:
{4-[Hydroxy(diphenyl)methyl]-2H-1,2,3-triazol-2-yl}[4-(2-methyl-2-propanyl)-1-piperidinyl]methanone
Methanone, [4-(1,1-dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-
ML-211

Biological Activity

[Description]:

ML-211 is a carbamate-based dual inhibitor of acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) (IC50=17 nM) and LYPLA2 (IC50=30 nM). ML-211 also inhibits theserine hydrolase ABHD11 with an IC50 value of 10 nM but is ≥ 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL

[References]

[1]. Adibekian, A., Martin, B.R., Speers, A.E., et al. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program 1 R01 CA132630, 1-42 (2013).

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
583.9±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₅H₃₀N₄O₂

[ Molecular Weight ]:
418.531

[ Flash Point ]:
306.9±27.9 °C

[ Exact Mass ]:
418.236877

[ LogP ]:
3.87

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.616

Related Compounds

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