MY10
Names
[ CAS No. ]:
2204270-73-3
[ Name ]:
MY10
Biological Activity
[Description]:
MY10 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation; blocks ethanol conditioned place preference, shows limited effects on ethanol-induced ataxia, and potentiates the sedative effects of ethanol in mice; increases levels of phosphorylated ALK and TrkA in neuroblastoma cells, modulates signaling pathways activated by alcohol.
[References]
References 1. Fernández-Calle R, et al. Neuropharmacology. 2018 May 9;137:86-95. View Related Products by Target Protein Phosphatase/PTP
Chemical & Physical Properties
[ Molecular Formula ]:
C15H10F6OS2
[ Molecular Weight ]:
384.354