Thalidomide-NH-PEG3-NH-Boc

Names

[ CAS No. ]:
2204246-03-5

[ Name ]:
Thalidomide-NH-PEG3-NH-Boc

Biological Activity

[Description]:

Thalidomide-NH-PEG3-NH-Boc is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-NH-PEG3-NH-Boc acts as a ligand for Cereblon to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-PEG3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-PEG3-NH-Boc is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₆N₄O₉

[ Molecular Weight ]:
548.59

[ Storage condition ]:
2-8°C

Related Compounds

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