Angstrom6

Names

[ CAS No. ]:
220334-14-5

[ Name ]:
Angstrom6

Biological Activity

[Description]:

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1

Research Areas >> Cancer

[In Vitro]

Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC50s in the range of 10 to 100 nM[3]. Angstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation[3].

[In Vivo]

Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%[3]. Animal Model: C57Bl/6 mice (bearing B16-F10 cells)[3] Dosage: 100 mg/kg Administration: S.c.; twice a day for 11 days Result: Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.

[References]

[1]. Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111(1):89-94.

[2]. Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30.

[3]. Piotrowicz RS, et al. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther. 2011;10(11):2072-2082.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₉H₆₂N₁₀O₁₅

[ Molecular Weight ]:
910.97

Related Compounds

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