HPK1-IN-15

HPK1-IN-15 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-15 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2018049200A1, compound 50)[1].

Signaling Pathways >> MAPK/ERK Pathway >> MAP4K

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[1]. Hai-Fen Ye, et al. Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer. Patent WO2018049200A1.