SB-357134
Names
[ CAS No. ]:
219963-52-7
[ Name ]:
SB-357134
Biological Activity
[Description]:
A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes; inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63, enhances memory and learning following chronic administration in mice.
[References]
References 1. Bromidge SM, et al. Bioorg Med Chem Lett. 2001 Jan 8;11(1):55-8. 2. Stean TO, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):645-54. 3. Marcos B, et al. Eur J Neurosci. 2006 Sep;24(5):1299-306. 4. Rogers DC, et al. Psychopharmacology (Berl). 2001 Nov;158(2):114-9. View Related Products by Target 5-HT Receptor
Chemical & Physical Properties
[ Molecular Formula ]:
C17H18Br2FN3O3S
[ Molecular Weight ]:
523.22