Griffipavixanthone

Names

[ CAS No. ]:
219649-95-3

[ Name ]:
Griffipavixanthone

[Synonym ]:
(8S,8aS,12aR)-1,3,6,7-Tetrahydroxy-9,9,11-trimethyl-8-(3,4,6,8-tetrahydroxy-9-oxo-9H-xanthen-1-yl)-8a,9,10,12a-tetrahydroindeno[1,2-a]xanthen-13(8H)-one
Indeno[1,2-a]xanthen-13(8H)-one, 8a,9,10,12a-tetrahydro-1,3,6,7-tetrahydroxy-9,9,11-trimethyl-8-(3,4,6,8-tetrahydroxy-9-oxo-9H-xanthen-1-yl)-, (8S,8aS,12aR)-

Biological Activity

[Description]:

Griffipavixanthone can be extracted from Garcinia schomburgkiana. Griffipavixanthone induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. Griffipavixanthone is an anti-cancer agent. Griffipavixanthone is a weak sucrase inhibitor (IC50: 4.58 mM)[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[References]

[1]. Lien Do TM, et al. Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana. Nat Prod Res. 2021 Nov;35(21):3613-3618.

[2]. Shi JM, et al. Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro. Molecules. 2014 Jan 27;19(2):1422-31.

[3]. Ma Y, et al. Griffipavixanthone induces apoptosis of human breast cancer MCF-7 cells in vitro. Breast Cancer. 2019 Mar;26(2):190-197.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
862.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₆H₂₈O₁₂

[ Molecular Weight ]:
652.60

[ Flash Point ]:
277.7±27.8 °C

[ Exact Mass ]:
652.158081

[ PSA ]:
222.26000

[ LogP ]:
4.32

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.772

Safety Information

[ Hazard Codes ]:
Xi