Bcl-2/Bcl-xl inhibitor 1

Names

[ Name ]:
Bcl-2/Bcl-xl inhibitor 1

Biological Activity

[Description]:

Bcl-2/Bcl-xl inhibitor 1 (compound 6) is a dual Bcl-2 and Bcl-xl inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Bcl-2/Bcl-xl inhibitor 1 exhibits IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family

Research Areas >> Cancer

[Target]

Bcl-2:2 nM (IC50)

Bcl-xL:5.9 nM (IC50)

[In Vitro]

Bcl-2/Bcl-xl inhibitor 1 (compound 6) exhibits IC50 values of 5.5 nM and 6.4 nM in Bcl-2 dependent RS4;11 cells and Bcl-xl dependent Molm13 cells[1].

[References]

[1]. WANG, Chia, et al. N-(PHENYLSULFONYL)BENZAMIDES AND RELATED COMPOUNDS AS BCL-2 INHIBITORS. Patent. WO2018027097A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₅H₄₈ClN₇O₈S

[ Molecular Weight ]:
882.42

[ Storage condition ]:
2-8°C

Related Compounds

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