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BCX 1470

Names

[ CAS No. ]:
217099-43-9

[ Name ]:
BCX 1470

[Synonym ]:
2-Carbamimidoyl-1-benzothiophen-6-yl 2-thiophenecarboxylate
2-Thiophenecarboxylic acid, 2-(aminoiminomethyl)benzo[b]thien-6-yl ester
BCX 1470||BCX 1470|BCX-1470
BCX 1470
CS-0313
2-carbamimidoyl-1-benzothiophen-6-yl thiophene-2-carboxylate
2-Carbamimidoyl-1-benzothiophen-6-ylthiophen-2-carboxylat
cc-543

Biological Activity

[Description]:

BCX 1470 inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM), 3.4- and 200-fold better, respectively, than that of trypsin.IC50 Value: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) [1]Target: Factor D; C1sBCX 1470(Thrombin inhibitor) is serine protease inhibitor.BCX 1470(Thrombin inhibitor) blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Complement System
Research Areas >> Inflammation/Immunology

[References]

[1]. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468


[Related Small Molecules]

Avacopan | W 54011 | Compstatin trifluoroacetate salt | BCX 1470 (methanesulfonate) | Leukadherin-1 | C3a (70-77) trifluoroacetate salt

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
509.9±58.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H10N2O2S2

[ Molecular Weight ]:
302.371

[ Flash Point ]:
262.2±32.3 °C

[ Exact Mass ]:
302.018372

[ PSA ]:
132.65000

[ LogP ]:
3.71

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.751

[ Storage condition ]:
2-8℃

Related Compounds