SHIP 2a

Names

[ CAS No. ]:
2165706-30-7

[ Name ]:
SHIP 2a

Biological Activity

[Description]:

Cystathionine-γ-lyase-IN-1 is a selective cystathionine γ-lyase (CSE) enzyme inhibitor with an IC50 of 6.3 μM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

[In Vitro]

Cystathionine-γ-lyase-IN-1 (comp 2a) completely abrogates L-cysteine-induced vasorelaxation at a concentration of 100 μM[1]. Cystathionine-γ-lyase-IN-1 (100 μM; 30 minutes) significantly inhibits the increased H2S production stimulated by L-Cys at a lower dose in mouse aorta homogenates[1]. Cystathionine-γ-lyase-IN-1 inhibits the enzyme completely, keeping the concentration of substrate unaffected[1].

[References]

[1]. Angela Corvino, et al. Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production. Sci Rep. 2016 Oct 6;6:34398.

Chemical & Physical Properties

[ Molecular Formula ]:
C₇H₈N₂O₂S

[ Molecular Weight ]:
184.22

Related Compounds

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