Obafistat

Names

[ Name ]:
Obafistat

[Synonym ]:
Methanone, [8-[(3-fluorophenyl)sulfonyl]-3,8-diazabicyclo[3.2.1]oct-3-yl]-1H-1,2,3-triazol-5-yl-
{8-[(3-Fluorophenyl)sulfonyl]-3,8-diazabicyclo[3.2.1]oct-3-yl}(1H-1,2,3-triazol-5-yl)methanone

Biological Activity

[Description]:

Obafistat is a potent aldo-keto reductase AKR1C3 inhibitor with an IC50 of 1.2 nM for human AKR1C3 (patent WO2017202817A1, example 4)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Marcus Koppitz, et al. [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl] (1h-1,2,3-triazol-4-yl)methanones. WO2017202817A1.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
623.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₆FN₅O₃S

[ Molecular Weight ]:
365.38

[ Flash Point ]:
330.8±34.3 °C

[ Exact Mass ]:
365.095795

[ LogP ]:
0.46

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.642

Related Compounds

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