ICT5040

Names

[ Name ]:
ICT5040

[Synonym ]:
Pyridine, 2-methyl-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)-
2-(methylthio)-5-[2-methyl-6-(trifluoromethyl)-3-pyridyl]-1,3,4-oxadiazole
2-Methyl-3-[5-(methylsulfanyl)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)pyridine
2-Methyl-3-[5-(methylthio)-1,3,4-oxadiazol-2-yl]-6-(trifluoromethyl)pyridine

Biological Activity

[Description]:

ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> CXCR

Signaling Pathways >> Immunology/Inflammation >> CXCR

[Target]

CXCR4:3.8 μM (IC50)

[In Vitro]

ICT5040 (1-100 μM; 0-4 d) 剂量依赖性地抑制 CXCL12 诱导的 U87 胶质瘤细胞的增殖和迁移[1]。 ICT5040 在 U87 胶质瘤细胞中降低 CXCL12 诱导的细胞内钙动员[1]。 Cell Migration Assay [1] Cell Line: U87-glioma cells Concentration: 1 μM, 10 μM, 100 μM; with 100 ng/mL CXCL12 Incubation Time: 0, 1, 2, 3, and 4 days Result: Resulted reduction of CXCL12 induced proliferation and migration of U87 cells at day 3.

[References]

[1]. Vinader V, et al. Discovery and computer aided potency optimization of a novel class of small molecule CXCR4 antagonists. PLoS One. 2013 Oct 18;8(10):e78744.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
343.5±52.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₈F₃N₃OS

[ Molecular Weight ]:
275.250

[ Flash Point ]:
161.5±30.7 °C

[ Exact Mass ]:
275.034027

[ LogP ]:
3.75

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.543

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.