WHI-P258

Names

[ Name ]:
WHI-P258

[Synonym ]:
4-Anilino-6,7-dimethoxychinazolin
6,7-dimethoxy-4-phenylaminoquinazoline
HMS1662N04
4-anilino-6,7-dimethoxyquinazoline
4-quinazolinamine, 6,7-dimethoxy-N-phenyl-
4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE
WHI-P258

Biological Activity

[Description]:

WHI-P258, a quinazoline compound, binds to the active site of JAK3 with an estimated Ki of 72 µM. WHI-P258 does not inhibit JAK3 and does not affect the thrombin-induced aggregation of platelets even at 100 μM[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> JNK

[References]

[1]. Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82.

[2]. Tibbles HE, et al. Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. J Biol Chem. 2001 May 25;276(21):17815-22.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
441.2±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₅N₃O₂

[ Molecular Weight ]:
281.309

[ Flash Point ]:
220.6±27.3 °C

[ Exact Mass ]:
281.116425

[ PSA ]:
56.27000

[ LogP ]:
2.87

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.663

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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