FR-190809

Names

[ CAS No. ]:
215589-63-2

[ Name ]:
FR-190809

[Synonym ]:
Urea,N-cycloheptyl-N-((4-(4-fluorophenoxy)phenyl)methyl)-N'-(6-methyl-2,4-bis(methylsulfonyl)-3-pyridinyl)
UNII-1U8UW770Z6

Biological Activity

[Description]:

FR-190809 is a potent, nonadrenotoxic, orally efficacious acyl-CoA:cholesterol O-acyltransferase (ACAT) inhibitor, with an IC50 of 45 nM[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> Metabolic Enzyme/Protease >> Acyltransferase

[Target]

IC50: (ACAT)[1]


[In Vitro]

FR-190809 inhibits foam cell formation with an IC50 of 215 nM[1].

[References]

[1]. Tanaka A, et al. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 3. Discovery of a novel series of N-alkyl-N-[(fluorophenoxy)benzyl]-N'-arylureas with weak toxicological effects on adrenal glands. J Med Chem. 1998 Oct 22;41(22):4408-20.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H34FN3O6S2

[ Molecular Weight ]:
603.72500

[ Exact Mass ]:
603.18700

[ PSA ]:
142.99000

[ LogP ]:
8.06050

Related Compounds