Ds28120313

Names

[ CAS No. ]:
2146177-09-3

[ Name ]:
Ds28120313

Biological Activity

[Description]:

DS28120313 (compound 32) is an orally hepcidin production inhibitor with an IC50 of 0.093 μM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 0.093 μM (hepcidin production)[1]

[In Vivo]

DS28120313 (deliver orally; 30 mg/kg; 30 min before IL-6 administration) inhibits hepcidin production and reduces the blood hepcidin level in IL-6 induced acute inflammatory C57BL/6 mouse model[1].

[References]

[1]. Fukuda T, et al. Discovery of DS28120313 as a potent orally active hepcidin production inhibitor: Design and optimization of novel 4,6-disubstituted indazole derivatives. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5252-5257.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₇N₅O₂

[ Molecular Weight ]:
311.34

Related Compounds

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