Thalidomide-4-NH-PEG1-COO(t-Bu)

Names

[ Name ]:
Thalidomide-4-NH-PEG1-COO(t-Bu)

[Synonym ]:
propanoic acid, 3-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1h-isoindol-4-yl]amino]etho

Biological Activity

[Description]:

Thalidomide-4-NH-PEG1-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-4-NH-PEG1-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-4-NH-PEG1-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> Ligand for E3 Ligase

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₇N₃O₇

[ Molecular Weight ]:
445.47

Related Compounds

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