diABZI-C2-NH2
Names
[ CAS No. ]:
2137975-93-8
[ Name ]:
diABZI-C2-NH2
Biological Activity
[Description]:
diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist[1].
[Related Catalog]:
[In Vitro]
The author developed a linking strategy to synergize the effect of two symmetry-related amidobenzimidazole (ABZI)-based compounds to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. Intravenous administration of a diABZI STING agonist to immunocompetent mice with established syngeneic colon tumours elicited strong anti-tumour activity, with complete and lasting regression of tumors[1]. diABZI-C2-NH2 is covalently immobilized on sepharose beads and is used to affinity-capture potential target proteins from a THP1 cell lysate[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C36H43N13O4
[ Molecular Weight ]:
721.81