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Dirocaftor

Names

[ CAS No. ]:
2137932-23-9

[ Name ]:
Dirocaftor

Biological Activity

[Description]:

Dirocaftor (PTI-808) is a CFTR potentiator that enhances the function of CFTR protein by opening chloride channels. Dirocaftor can be used for cystic fibrosis (CF) research[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR
Research Areas >> Inflammation/Immunology

[In Vitro]

When combined with Nesolicaftor and Posenacaftor, Dirocaftor can restore CFTR function to nearly normal levels[2].

[References]

[1]. James A Reihill, et al. Modulation of Ion Transport to Restore Airway Hydration in Cystic Fibrosis. Genes (Basel). 2021 Mar 22;12(3):453.

[2]. P. van Mourik, et al. WS10 Moving beyond body mass index to assess nutritional status in CF. Journal of Cystic Fibrosis 19S2 (2020) S1-S36.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H28N2O3Si2

[ Molecular Weight ]:
424.64

Related Compounds