LSD1-IN-32

Names

[ Name ]:
LSD1-IN-32

Biological Activity

[Description]:

LSD1-IN-32 is a potent, reversible lysine specific demethylase 1 (LSD1) inhibitor with biochemical IC50 of 83 nM, Kd of 32 nM, cell EC50 of 0.67 uM; display much greater levels of selectivity over the hERG cardiac ion channel than GSK-690; shows significant anti-proliferative activity, promotes the differentiation of AML cells, with concomitant reduction in clonogenic potential.

[References]

References 1. Mould DP, et al. J Med Chem. 2017 Oct 12;60(19):7984-7999. View Related Products by Target Histone Demethylase

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₇FN₄O₂

[ Molecular Weight ]:
422.504

Related Compounds

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