Epcoritamab

Names

[ Name ]:
Epcoritamab

Biological Activity

[Description]:

Epcoritamab (GEN3013) is an bispecific IgG1 antibody redirecting T-cells toward CD3×CD20+ tumor cells. Epcoritamab induces potent T-cell-mediated cytotoxicity towards B-cell NHL cell lines[1].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Epcoritamab (30 ng/mL) 在健康供体外周血单核细胞 (PBMC) 存在的情况下诱导有效的细胞毒性[1]。

[References]

[1]. van der Horst HJ, et al. Epcoritamab induces potent anti-tumor activity against malignant B-cells from patients with DLBCL, FL and MCL, irrespective of prior CD20 monoclonal antibody treatment. Blood Cancer J. 2021 Feb 18;11(2):38.

[2]. Thieblemont C, et al. Epcoritamab, a Novel, Subcutaneous CD3xCD20 Bispecific T-Cell-Engaging Antibody, in Relapsed or Refractory Large B-Cell Lymphoma: Dose Expansion in a Phase I/II Trial. J Clin Oncol. 2023 Apr 20;41(12):2238-2247.

Chemical & Physical Properties

No Any Chemical & Physical Properties