S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate

Names

[ Name ]:
S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate

Biological Activity

[Description]:

S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) and refers to the Alkyl-Chain composition. S-(1-Hydroxy-2-methylpropan-2-yl) methanesulfonothioate is the linker portions of the molecules employed for mAb attachment purposes[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[References]

[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31.

Chemical & Physical Properties

[ Molecular Formula ]:
C₅H₁₂O₃S₂

[ Molecular Weight ]:
184.28

[ Storage condition ]:
2-8°C

Related Compounds

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