IDO1-IN-22

Names

[ CAS No. ]:
2126853-16-3

[ Name ]:
IDO1-IN-22

Biological Activity

[Description]:

IDO1-IN-22 (Compound 3) is a IDO1 inhibitor (biochemical hIDO1 IC50: 67.4 nM, HeLa hIDO1 IC50: 17.6 nM). IDO1-IN-22 has excellent antitumor efficacy in LLC xenograft model, as well as desirable pharmacokinetic (PK) profile[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Research Areas >> Inflammation/Immunology

[References]

[1]. Ye K, et al. Design, synthesis, biological evaluation of urea substituted 1,2,5-oxadiazole-3-carboximidamides as novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors. Eur J Med Chem. 2023 Mar 15;250:115217.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H12BrFN6O3

[ Molecular Weight ]:
387.16

Related Compounds

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