Vatalanib succinate

Names

[ Name ]:
Vatalanib succinate

[Synonym ]:
N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine, butanedioate (1:1)
PTK787
1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine succinate
Succinic acid - N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1)
1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1)
N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate
N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate (1:1)
(4-Chlorophenyl)[4-(pyridin-4-ylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate
N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine butanedioate (1:1)
(4-Chlorophenyl)[4-(4-pyridylmethyl)-phthalazin-1-yl]ammonium hydrogen succinate
Vatalanib
T66 CNNJ BMR DG& E1- DT6NJ &&Succinate
Vatalanib succinate
PTK/ZK

Biological Activity

[Description]:

Vatalanib (PTK787) succinate is a potent and orally active VEGFR inhibitor with IC50s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

KDR:37 nM (IC50)

Flt-1:77 nM (IC50)

Flt-4:730 nM (IC50)

[References]

[1]. J M Wood, et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 2000 Apr 15;60(8):2178-89.

Chemical & Physical Properties

[ Boiling Point ]:
587.8ºC at 760 mmHg

[ Melting Point ]:
195ºC

[ Molecular Formula ]:
C₂₄H₂₁ClN₄O₄

[ Molecular Weight ]:
464.90

[ Flash Point ]:
309.3ºC

[ Exact Mass ]:
464.125122

[ PSA ]:
125.30000

[ LogP ]:
5.02140

[ Vapour Pressure ]:
8.48E-14mmHg at 25°C

Related Compounds

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