Dendrobine

Names

[ Name ]:
Dendrobine

[Synonym ]:
Dendroban-12-one
Dendroban-12-on
12-Oxodendrobane
Dendrobine
5,8-Methano-6H-7-oxa-1-azacyclopent[cd]azulen-6-one, decahydro-1,8b-dimethyl-9-(1-methylethyl)-, (2aS,4aS,5R,8R,8aS,8bR,9S)-

Biological Activity

[Description]:

Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

[Target]

IC50: 3.39 μM (A/FM-1/1/47), 2.16 μM (A/Puerto Rico/8/34 H274Y), 5.32 μM (A/Aichi/2/68)[1]

[References]

[1]. Li R, et al. Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action. J Agric Food Chem. 2017 May 10;65(18):3665-3674.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
374.6±25.0 °C at 760 mmHg

[ Melting Point ]:
135-136℃

[ Molecular Formula ]:
C₁₆H₂₅NO₂

[ Molecular Weight ]:
263.375

[ Flash Point ]:
132.8±14.0 °C

[ Exact Mass ]:
263.188538

[ PSA ]:
29.54000

[ LogP ]:
1.88

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.526

[ Storage condition ]:
2-8℃

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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