CLK inhibitor T3

Names

[ Name ]:
CLK inhibitor T3

[Synonym ]:
4-[2-Methyl-1-(4-methyl-1-piperazinyl)-1-oxo-2-propanyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide
MFCD31689325
Benzamide, 4-[1,1-dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]-

Biological Activity

[Description]:

CLK inhibitor T3 (T3) is a highly potent, selective, and cell-based stable CDC-like kinase (CLK) inhibitor with 0.67, 15 and 110 nM for CLK1,2 and 3, respectively; displays 200-300-fold selectivity over other dual specificity kinases such as DYRK1A and DYRK1B; induces dose-dependent reduction in exon recognition and exhibits an overlapping, but greater effect on transcriptome splicing compared to KH-CB19.

[References]

References 1. Funnell T, et al. Nat Commun. 2017 Feb 23;8(1):7. View Related Products by Target Cdc2-like Kinase (CLK)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₈H₃₀N₆O₂

[ Molecular Weight ]:
482.577

[ Exact Mass ]:
482.243011

[ LogP ]:
2.36

[ Index of Refraction ]:
1.659

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.