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JNJ-64264681

Names

[ CAS No. ]:
2101524-34-7

[ Name ]:
JNJ-64264681

Biological Activity

[Description]:

JNJ-64264681 is a potent, orally active, selective and irreversible covalent BTK inhibitor. JNJ-64264681 exhibits good pharmacokinetic characteristics and can be used for cancer and autoimmune diseases research[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[References]

[1]. Mark S Tichenor, et al. Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J Med Chem. 2022 Nov 10;65(21):14326-14336.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H30N6O3S

[ Molecular Weight ]:
518.63

Related Compounds