PI3Kα-IN-4h

Names

[ Name ]:
PI3Kα-IN-4h

Biological Activity

[Description]:

PI3Kα-IN-1 is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively; displays good selectivity for PI3Kα; demonstrates cytotoxicity in MCF7 cells, reasonable toxicity in MDA-MB-468 cells, good therapeutic index compared to normal skin fibroblasts, and acceptable in vitro ADME properties.

[References]

References 1. Al-Ashmawy AAK, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3117-3122. View Related Products by Target PI3K

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₅N₇O₃

[ Molecular Weight ]:
483.532

Related Compounds

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