DBCO-NHCO-PEG4-NHS ester

Names

[ Name ]:
DBCO-NHCO-PEG4-NHS ester

Biological Activity

[Description]:

DBCO-NHCO-PEG4-NHS ester ester is a MMP-2- and cathepsin B- (CatB) cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Thornlow DN, et al. Dual Site-Specific Antibody Conjugates for Sequential and Orthogonal Cargo Release. Bioconjug Chem. 2019 Jun 19;30(6):1702-1710.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₃₉N₃O₁₀

[ Molecular Weight ]:
649.69

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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