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Sodium Aescinate

Names

[ CAS No. ]:
20977-05-3

[ Name ]:
Sodium Aescinate

[Synonym ]:
3-methyl-pyridine-2-carbonitrile
3-methyl-2-pyridinecarbonitrile
2-cyano-3-methly pyridine
2-cyano-b-picoline
3-methylpyridine-2-carbonitrile
2-Cyano-3-methylpyridine
(h4tes4)[qr]
akrochem tdec
diethyl-carbamodithioicacitetrakis(anhydrosulfide)withthiotelluricac
Sodium escinate

Biological Activity

[Description]:

Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities[1]. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Sodium aescinate can block signals transiting to downstream molecules AKT, ERK, inhibit the proliferation of breast cancer cell MCF-7 cell apoptosis and induced cell apoptosis by suppressing the activation of SRC[3].

[In Vivo]

Sodium aescinate may effectively controls and improves wound healing in diabetic rats via its anti-inflammatory and antioxidant activities[1]. Sodium aescinate treatment can alleviate the symptom of polycystic ovary syndrome (PCOS) in rat model through regulating the PI3K/Akt/GSK3-β pathway[4].

[References]

[1]. Zhang Z, et al. The Efficacy of Sodium Aescinate on Cutaneous Wound Healing in Diabetic Rats. Inflammation. 2015 Oct;38(5):1942-8.

[2]. Hou H, et al. CARMA3/NF-κB signaling contributes to tumorigenesis of hepatocellular carcinoma and is inhibited by sodium aescinate. World J Gastroenterol. 2019 Sep 28;25(36):5483-5493.

[3]. Qi SM, et al. Effect of sodium aescinate in inducing human breast cancer MCF-7 cells apoptosis by inhibiting AKT, ERK and upstream signal SRC activity. Zhongguo Zhong Yao Za Zhi. 2015 Aug;40(16):3267-72.

[4]. Chen L, et al. Effect of sodium aescinate treatment on PCOS rat model with insulin resistance. Bratisl Lek Listy. 2017;118(4):223-227.

Chemical & Physical Properties

[ Molecular Formula ]:
C54H83NaO23

[ Molecular Weight ]:
1124.2202

Related Compounds