Anticancer agent 109

Names

[ CAS No. ]:
2097497-16-8

[ Name ]:
Anticancer agent 109

Biological Activity

[Description]:

Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor

[Target]

Axl

[References]

[1]. Bae D, et al. Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis. Eur J Med Chem. 2023 May 5;251:115274.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₅N₃O₂

[ Molecular Weight ]:
317.34

Related Compounds

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