DPPY

Names

[ CAS No. ]:
2095883-62-6

[ Name ]:
DPPY

Biological Activity

[Description]:

DPPY (compound 6) is a potent PTK inhibitor with IC50 values of <10, <10, <10 nM for EGFR, BTK, JAK3, respectively. DPPY shows anti-proliferative activity against B-cell lymphoma cells. DPPY has the potential for the research of idiopathic pulmonary fibrosis (IPF)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

[Target]

JAK3:<10 nM (IC50)

EGFR:<10 nM (IC50)

BTK:<10 nM (IC50)


[References]

[1]. Zhu Y, et al. Synthesis and biological activity of thieno[3,2-d]pyrimidines as potent JAK3 inhibitors for the treatment of idiopathic pulmonary fibrosis. Bioorg Med Chem. 2020 Jan 15;28(2):115254.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H26ClN7O3

[ Molecular Weight ]:
507.97

Related Compounds