AY 254

Names

[ CAS No. ]:
2093408-03-6

[ Name ]:
AY 254

Biological Activity

[Description]:

AY 254 is a potent PAR2 biased agonist. Selectively activates ERK1/2 signaling (EC50= 2 nM for ERK1/2 phosphorylation versus 80 nM for Ca2+release). Reduces cytoKi ne-induced caspase 3/8 activation, promotes scratch-wound healing, and induces IL-8 secretion, in human colorectal cancer (HT29) cellsin vitro.

[References]

1. Jiang et al (2017) Biased signaling by agonists of protease activated receptor 2. ACS Chem.Biol. 12 1217 PMID: 28169521

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₀H₄₉N₉O₆

[ Molecular Weight ]:
631.779

Related Compounds

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