ML233

Names

[ CAS No. ]:
2080311-92-6

[ Name ]:
ML233

Biological Activity

[Description]:

ML233 is a non-peptide based potent apelin receptor (APJ) agonist (EC50=3.7 μM). ML233 displays >21-fold selective over the closely related angiotensin 1 (AT1) receptor (>79 μM)[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[Target]

EC50: 3.7 μM (Apelin receptor)[1]

[In Vitro]

ML233 shows potentially significant binding against several other receptors, including the 5-HT1A, α2C adrenergic, and benzylpiperazine receptors and norepinephrine transporter. ML233 shows some toxicity (LC50=25.8 μM) toward human hepatocyctes[1].

[References]

[1]. Khan P. National Center for Biotechnology Information; 2011. Functional agonists of the apelin (APJ) receptor. In Probe Reports from the NIH Molecular Libraries Program.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₁NO₄S

[ Molecular Weight ]:
359.44

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.