4'-O-Methylbroussochalcone B

Names

[ CAS No. ]:
20784-60-5

[ Name ]:
4'-O-Methylbroussochalcone B

[Synonym ]:
batracyclin
4,2'-dihydroxy-4'-methoxy-5'-prenylchalcone
2-Propen-1-one, 1-[2-hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2E)-
(2E)-1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
bavachalcone
Batracylin
4'-O-Methyl-bavachalcon
Daniquidone
(2E)-1-[2-Hydroxy-4-methoxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
4'-O-Methylbroussochalcone B

Biological Activity

[Description]:

4'-O-Methylbavachalcone is a chalcone isolated from Psoralea corylifolia, inhibits severe acute respiratory syndrome coronavirus (SARS-CoV) papain-like protease (PLpro) activity, with an IC50 of 10.1 μM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 10.1 μM (PLpro)[1]

[References]

[1]. 4'-O-Methylbavachalcone, et al. Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. J Enzyme Inhib Med Chem. 2014 Feb;29(1):59-63.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
552.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₂O₄

[ Molecular Weight ]:
338.397

[ Flash Point ]:
194.9±23.6 °C

[ Exact Mass ]:
338.151794

[ PSA ]:
66.76000

[ LogP ]:
5.84

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.622

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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