IWP-O1

Names

[ CAS No. ]:
2074607-48-8

[ Name ]:
IWP-O1

Biological Activity

[Description]:

IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells, suppressing the phosphorylation of Dvl2/3 and LRP6 in HeLa cells. IWP-O1 functions by preventing the secretion of Wnt proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Stem Cell/Wnt >> Wnt

Signaling Pathways >> Stem Cell/Wnt >> Porcupine

[Target]

EC50: 80 pM (Porcn)[1].

[References]

[1]. You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₂₀N₆O

[ Molecular Weight ]:
432.48

[ Storage condition ]:
-20℃

Related Compounds

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