GNE-7915 tosylate
Names
[ CAS No. ]:
2070015-00-6
[ Name ]:
GNE-7915 tosylate
Biological Activity
[Description]:
GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species. Parkinson's Disease Preclinical
[References]
References 1. Estrada AA, et al. J Med Chem. 2012 Nov 26;55(22):9416-33. 2. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15. 3. Kavanagh ME, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6. View Related Products by Target LRRK2 Parkinson Disease
Chemical & Physical Properties
[ Molecular Formula ]:
C26H29F4N5O6S
[ Molecular Weight ]:
615.597
[ Storage condition ]:
2-8℃
Related Compounds
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