MRT68921 hydrochloride

Names

[ CAS No. ]:
2070014-87-6

[ Name ]:
MRT68921 hydrochloride

[Synonym ]:
Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-, hydrochloride (1:1)
N-[3-({5-Cyclopropyl-2-[(2-methyl-1,2,3,4-tetrahydro-6-isoquinolinyl)amino]-4-pyrimidinyl}amino)propyl]cyclobutanecarboxamide hydrochloride (1:1)
MFCD30187515
BS-16452

Biological Activity

[Description]:

MRT68921 hydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Autophagy >> ULK

[References]

[1]. Petherick KJ, et al. Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J Biol Chem. 2015 May 1;290(18):11376-83.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₅ClN₆O

[ Molecular Weight ]:
471.038

[ Exact Mass ]:
470.256073

Related Compounds

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