Osocimab

Names

[ CAS No. ]:
2056878-75-0

[ Name ]:
Osocimab

Biological Activity

[Description]:

Osocimab (BAY 1213790), an anti-FXIa antibody (Ki=2.4 nM; EC50=0.2 nM). FXI inhibition may reduce the risk of thrombosis. Osocimab inhibits thrombin generation, and prolongs activated partial thromboplastin time. Osocimab exhibits anticoagulant effects[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa

[In Vitro]

Osocimab (1.4 nM-1 μM；30 分钟) 抑制凝血酶生成，同时抑制人血浆中 FXIa 介导的 FIX 激活 (或 FIX 转化) (IC50=16 nM) 和 FXIa 介导的底物裂解 (IC< sub>50=1.2 nM)[1]。 Osocimab (22.05 mg/mL) 抑制内在通路介导的凝血级联激活[1]。

[References]

[1]. Schaefer M, et al. Allosteric Inhibition as a New Mode of Action for BAY 1213790, a Neutralizing Antibody Targeting the Activated Form of Coagulation Factor XI. J Mol Biol. 2019 Dec 6;431(24):4817-4833.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.