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Carboxyrhodamine 110-PEG4-alkyne

Names

[ CAS No. ]:
2055103-66-5

[ Name ]:
Carboxyrhodamine 110-PEG4-alkyne

Biological Activity

[Description]:

Carboxyrhodamine 110-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C32H33N3O8

[ Molecular Weight ]:
587.62

Related Compounds