(S)-Erypoegin K

Names

[ CAS No. ]:
2055053-90-0

[ Name ]:
(S)-Erypoegin K

Biological Activity

[Description]:

(S)-Erypoegin K is a potent anticancer agent. (S)-Erypoegin K shows potent anti-proliferative activity against HL-60 cells. (S)-Erypoegin K induces apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

(S)-Erypoegin K (0-1 µM; 48 h)shows potent anti-proliferative activity against HL-60 cells with an IC50 of 90 nM[1]. (S)-Erypoegin K (0.1, 0.5 µM; 24 h) induces marked activation of caspase-3 and −9 in HL-60 cells in a time- and dose-dependent manner[1].

[References]

[1]. Hikita K, et al. Induction of enantio-selective apoptosis in human leukemia HL-60 cells by (S)-erypoegin K, an isoflavone isolated from Erythrina poeppigiana. Bioorg Med Chem. 2020 Jun 1;28(11):115490.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₈O₆

[ Molecular Weight ]:
354.35

Related Compounds

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