2(1H)-Pyrimidinethione,tetrahydro-

Names

[ CAS No. ]:
2055-46-1

[ Name ]:
2(1H)-Pyrimidinethione,tetrahydro-

[Synonym ]:
MFCD00060526
3,4,5,6-TETRAHYDRO-2-PYRIMIDINETHIOL
EINECS 218-152-3
Propylenethiourea (PTU)

Chemical & Physical Properties

[ Density]:
1.2 g/cm3

[ Boiling Point ]:
171.6ºC at 760 mmHg

[ Melting Point ]:
210-212 °C(lit.)

[ Molecular Formula ]:
C₄H₈N₂S

[ Molecular Weight ]:
116.18500

[ Flash Point ]:
57.6ºC

[ Exact Mass ]:
116.04100

[ PSA ]:
56.15000

[ LogP ]:
0.51180

[ Vapour Pressure ]:
1.38mmHg at 25°C

[ Index of Refraction ]:
1.596

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UW5782000

CHEMICAL NAME :: 2(1H)-Pyrimidinethione, tetrahydro-

CAS REGISTRY NUMBER :: 2055-46-1

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H8-N2-S

MOLECULAR WEIGHT :: 116.20

WISWESSER LINE NOTATION :: T6MYMTJ BUS

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,214,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1633 No. of Facilities: 208 (estimated) No. of Industries: 5 No. of Occupations: 7 No. of Employees: 771 (estimated) No. of Female Employees: 281 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UW5782000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

International safety assessment of pesticides: dithiocarbamate pesticides, ETU, and PTU--a review and update.

Teratog. Carcinog. Mutagen. 15(6) , 313-37, (1995)

For the last 30 years the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) has carried out toxicological evaluations and safety assessments of dithiocarbamate pesticides, continuously adjusting prev...

[Teratogenic and goitrogenic activity of propineb and propylenethiourea in the rat].

Boll. Soc. Ital. Biol. Sper. 61(2) , 271-8, (1985)

The teratogenic and goitrogenic effects of Propineb, dithiocarbamate pesticide and Propylenthiourea (PLTU), its metabolite and degradation product have been studied. The aim of this study was to show ...

Liquid chromatography coupled to tandem mass spectrometry for the residue determination of ethylenethiourea (ETU) and propylenethiourea (PTU) in water

J. Chromatogr. A. 1243 , 53-61, (2012)

Highlights ► Dithiocarbamates degradation products ETU and PTU are determined at sub-ppb levels in water. ► Rapid ETU and PTU determination by direct injection in UHPLC–MS/MS QqQ (LOD 0.058μg/L). ► Al...