BTX161

Names

[ CAS No. ]:
2052301-24-1

[ Name ]:
BTX161

Biological Activity

[Description]:

BTX161 is a thalidomide analog that mediates degradation of CKIα better than lenalidomide in human AML cells and activates DDR and p53, while stabilizing the p53 antagonist MDM2; upregulates all the Wnt targets including MYC and does not affect MDM2 mRNA expression.

[References]

References 1. Minzel W, et al. Cell. 2018 Aug 20. pii: S0092-8674(18)30973-5. doi: 10.1016/j.cell.2018.07.045. View Related Products by Target Casein Kinase

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₆N₂O₃

[ Molecular Weight ]:
272.304

Related Compounds

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